Efficacy of Mangifera indica L. seed kernel and Commiphora myrrha (Nees) Engl. gum extracts as potent adenosine A1 receptors |
( Volume 7 Issue 7,July 2020 ) OPEN ACCESS |
Author(s): |
Intisar Salih Ahmed, Aisha Zoheir Almagboul |
Keywords: |
Mangifera indica, Commiphora myrrha, isolated compounds, adenosine A1 receptor, anti-inflammatory |
Abstract: |
Although specific evaluation of the antimicrobial and anti-inflammatory efficacy of Mangifera indica L. and Commiphora myrrha (Nees) Engl. have been widely reported, their potential as adenosine A1 receptors were not investigated. The proposed study envisages evaluating the isolated compounds from the Mangifera indica L. (mango) seed kernel and myrrha gum by bioassay guided fractionation process using the adenosine A1 receptor binding assay in correlation with their anti-inflammatory activity and characterize them by spectroscopy techniques. The isolated compounds, hydroxy-xanthone-glucoside and quercetin-3-sulphate from Mangifera indica (M. indica) seed and quercetin from Commiphora myrrha (C. myrrha ) gum exhibited high percentage of displacement of [3H]-DPCPX radioactive ligand, and therefore showed high affinity to A1- receptor with Ki values in the micromolar range. |
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