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ISSN:2394-3661 | Crossref DOI | SJIF: 5.138 | PIF: 3.854

International Journal of Engineering and Applied Sciences

(An ISO 9001:2008 Certified Online and Print Journal)

Synthesis of Benzimidazole Derived Chalcones and their Heterocyclic Derivatives

( Volume 3 Issue 6,June 2016 ) OPEN ACCESS
Author(s):

Mohamad F.Ali, Abdulrahim M Khlafulla, Reem mohamed

Abstract:

A number of benzimidazole derivatives were prepared via the condensation reaction of o-phenylene diamine with various aromatic carboxylic acids in the presence of hydrochloric acid. The acetylated benzimidazoles then allowed to react with benzaldehyde derivatives to give chalcones. In order to achieve the final heterocyclic compounds those chalcones were treated with hydroxylamine hydrochloride, hydrazine hydrate and thiourea through Claisen-Schmidt condensation. The structure of all synthesized compounds were established by physical and spectral methods.

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