Identification and Evaluation of Coagulation Promotors on Surface of Medical Materials

Akari Goto, Kunihiko Ishihara

Blood coagulation reaction. Hemodialysis therapy, Thrombin, Materials

During hemodialysis treatment, ｍany problems such as residual blood, thrombocytopenia, coagulation in the blood circuit occur due to the patient’s blood contacting with various materials. Then in this paper, we will propose to evaluate the thrombin activity caused by contact between blood and material as an evaluation method of the antithrombotic medical material.

In the previous study, as the objective of elucidation of the blood coagulation mechanism, thrombin-like activity remained on the surface of the medical materials was measured and compared in order to evaluate the difference of materials for the blood coagulation activation which is caused in the case of the blood contacting the medical materials outside the living body.

In the previous study, thrombin-like activity is confirmed for five kinds of materials such as polystyrene, polymethylpentene, polyoropylene, tetrafluoroethylene, perfluoroalkoxyethylene and glass. In the present study, it was clarified that the coagulation promoter adsorbed on the surface of the material was thrombin due to the experiment using anti-thrombin antibody.

https://dx.doi.org/10.31873/IJEAS.8.4.08