3-Quinonlinecarbaldehyde thiosemicarbazones: Synthesis from N-arylacetamide, Characterization, Antibacterial and Antioxidant activities

Sreenivasulu Enumula, Satish Mudam, Khursheed Ahmed

Four different Schiff bases of 3-quinolinecarbaldehydes are synthesized from differently substituted thiosemicarbazides. The structures of compounds are established using modern analytical technique FT-IR, 1H-NMR and mass spectral data. Antimicrobial screening results are also presented against clinical isolates of pathogenic strains of Staphylococcus aureus, and E. coli. Simultaneously, antioxidant activities also have been carried out using DPPH radical scavenging properties to understand other functional applications of compounds. Depending on the structures of four synthesized compound, the compound d showed higher free radical neutralizing abilities as well as antimicrobial activities that may be due to the presence of 6-flouro group of the quinoline which might be facilitating the flow of electrons through polarization of electron density of the quinoline ring.